Endogenous GABA controls oligodendrocyte lineage cell number, myelination, and CNS internode length
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چکیده
منابع مشابه
Endogenous GABA controls oligodendrocyte lineage cell number, myelination, and CNS internode length
Adjusting the thickness and internodal length of the myelin sheath is a mechanism for tuning the conduction velocity of axons to match computational needs. Interactions between oligodendrocyte precursor cells (OPCs) and developing axons regulate the formation of myelin around axons. We now show, using organotypic cerebral cortex slices from mice expressing eGFP in Sox10-positive oligodendrocyte...
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CNS myelination and the maturation of the myelinating cells of the CNS, namely oligodendrocytes, are thought to be regulated by molecular mechanisms controlling the actin cytoskeleton. However, the exact nature of these mechanisms is currently only poorly understood. Here we assessed the role of calcium/calmodulin-dependent kinase type II (CaMKII), in particular CaMKII , in oligodendrocyte matu...
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ژورنال
عنوان ژورنال: Glia
سال: 2016
ISSN: 0894-1491
DOI: 10.1002/glia.23093